Tag Archives: outcomes

Improved survival in non-Ashkenazi Jewish ovarian cancer patients with BRCA1 and BRCA2 gene mutations

A new study shows that ovarian cancer patients who had the non-Askenazi Jewish BRCA mutation had longer Progression Free Surivival time and Overall Survival times than ovairan cancer patients who … Continue reading 

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Ovarian cancer spread missed when recommended staging biopsies not performed, UC Davis researchers find

UC Davis researchers have found that “[m]ore than a quarter of women with apparent early ovarian cancer do not receive the lymph node biopsies proven to improve patient survival”.  Their … Continue reading 

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Ovarian cancer in the elderly patient: are we doing enough?

INTRODUCTION: ovarian cancer is deadly and frequently affects older patients. In the next 20 years, the number of patients over 65 will double, and cancer, including ovarian cancer, will increase … Continue reading 

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Unrealistic Optimism in Early-Phase Oncology Trials

A new report questions the ethics of early stage oncology clinical trials, asserting that since patients have unrealistically high expectations of the outcomes of the trials, a question of informed … Continue reading 

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Chemosensitivity Assays for Ovarian Cancer

Point: Chemosensitivity Assays Have a Role in the Management of Recurrent Ovarian Cancer In this era of personalized medicine, patients with recurrent ovarian cancer deserve better than the 25% response … Continue reading 

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Chemosensitivity and outcome of BRCA1- and BRCA2-associated ovarian cancer patients after first-line chemotherapy compared with sporadic ovarian cancer patients

Background: Because it is insufficiently clear whether BRCA-associated epithelial ovarian cancer (EOC) is more chemosensitive than sporadic EOC, we examined response to chemotherapy, progression-free survival (PFS) and overall survival (OS) … Continue reading 

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Topotecan Weekly Versus Conventional 5-Day Schedule in Patients With Platinum-Resistant Ovarian Cancer: A Randomized Multicenter Phase II Trial of the North-Eastern German Society of Gynecological Oncology Ovarian Cancer Study Group

Purpose Weekly administration of topotecan (Tw) is less toxic and widely considered a better treatment option than conventional 5-day therapy (Tc) in women with platinum-resistant recurrent ovarian cancer. We conducted … Continue reading 

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Randomized Phase III Clinical Trial Evaluating Weekly Cisplatin for Advanced Epithelial Ovarian Cancer

This randomized, open label, phase III clinical trial (1988–1992) compared the efficacy and safety of a dose-dense regimen of single-agent cisplatin with a standard 3-weekly schedule in first-line chemotherapy for … Continue reading 

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Study examines end-of-life care for cancer patients

Many in their final days receive costly, aggressive treatments they may not want, according to researchers at the Dartmouth Atlas of Health Care. In California, Los Angeles County had the … Continue reading 

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Hormone Therapy Linked to Ovarian Cancer

Estrogen-Only Therapy More Strongly Associated With Greater Risk for Ovarian Cancer Postmenopausal women who use hormone replacement therapy face a 29% increased risk of ovarian cancer, according to a study. … Continue reading 

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Use of Paclitaxel for Advanced Ovarian Cancer in Clinical Practice: Analysis of 541 Patients. Results from a German Multi-centre Observational Study

Paclitaxel is one of the most common antitumour agents paclitaxel for the treatment of primary and relapsed ovarian cancer. Based on a German multicentre observational study, this article reflects the … Continue reading 

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Prognostic role of platinum sensitivity in patients with brain metastases from ovarian cancer: results of a German multicenter study

Background: Ovarian cancer is the leading cause of death in women with gynecological malignancies. Brain metastases are considered an uncommon metastatic site. Only few data exist on prognostic factors for … Continue reading 

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