Tag Archives: genetics

Company appeals genetic patent ruling

A Salt Lake City company says it is appealing a U.S. District Court ruling invalidating its patents on naturally occurring genes. In March, U.S. District Judge Robert Sweet in New … Continue reading 

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New Strategies in Ovarian Cancer: Uptake and experience of women at high risk of ovarian cancer who are considering risk-reducing salpingo-oophorectomy

This paper reviews factors associated with uptake of risk-reducing salpingo-oophorectomy by women at increased hereditary risk for ovarian cancer, as well as quality of life issues following surgery. Forty one … Continue reading 

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BRAF Mutation Is Rare in Advanced-Stage Low-Grade Ovarian Serous Carcinomas

Low-grade ovarian serous carcinomas are believed to arise via an adenoma-serous borderline tumor-serous carcinoma sequence. In this study, we found that advanced-stage, low-grade ovarian serous carcinomas both with and without … Continue reading 

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Gene studies zero in on breast, ovarian cancer risk

Scientists have found a region of DNA that can increase or decrease the high chance of breast cancer linked to a particular gene variant — a finding that could help … Continue reading 

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Artificial Ovary Could Help Infertile Women

Tissue engineering allows for complex three-dimensional cell construction. Researchers at Brown University have created an “artificial human ovary” using a tissue engineering approach that they hope will one day allow … Continue reading 

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National Hereditary Breast and Ovarian Cancer Week Designated

The House of Representatives voted in favor of a House Resolution sponsored by Rep. Wasserman Schultz (FL-20) to designate the last week of September as National Hereditary Breast and Ovarian … Continue reading 

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ARID1A Mutations in Endometriosis-Associated Ovarian Carcinomas (NEJM)

Background Ovarian clear-cell and endometrioid carcinomas may arise from endometriosis, but the molecular events involved in this transformation have not been described. Methods We sequenced the whole transcriptomes of 18 … Continue reading 

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DNA Dilemma: The Full Interview With the FDA on DTC Genetic Tests (Newsweek)

In an interview yesterday, the FDA made some potentially controversial and confusing statements about consumer genetics, an area it’s in the process of deciding how to regulate. I criticize the … Continue reading 

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Personalizing Therapy for Ovarian Cancer: BRCAness and Beyond

Although 70% to 80% of epithelial ovarian cancers respond to chemotherapy, less than 30% of patients can be cured with cytoreductive surgery combined with the best currently available drugs. Over … Continue reading 

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Gene Expression Profile of BRCAness That Correlates With Responsiveness to Chemotherapy and With Outcome in Patients With Epithelial Ovarian Cancer

Purpose To define a gene expression profile of BRCAness that correlates with chemotherapy response and outcome in epithelial ovarian cancer (EOC). Methods A publicly available microarray data set including 61 … Continue reading 

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Somatic Mutations in BRCA1 and BRCA2 Could Expand the Number of Patients That Benefit From Poly (ADP Ribose) Polymerase Inhibitors in Ovarian Cancer

Purpose The prevalence of BRCA mutations in germline DNA from unselected ovarian cancer patients is 11% to 15.3%. It is important to determine the frequency of somatic BRCA changes, given … Continue reading 

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A KRAS-Variant in Ovarian Cancer Acts as a Genetic Marker of Cancer Risk

Ovarian cancer (OC) is the single most deadly form of women’s cancer, typically presenting as an advanced disease at diagnosis in part due to a lack of known risk factors … Continue reading 

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