Tag Archives: genetics
New Insights into BRCA1 Mechanism
A study published in Nature posits that the BRCA1 mutation prevents cancer by preventing transcription of certain kinds of DNA sequences. Women with mutations in the BRCA1 genes are at higher risk of developing breast and ovarian cancer. See the … Continue reading
PAPR Inhibitors May Work Against More Ovarian Cancers
PAPR inhibitors, first used in trials for women with ovarian cancer who had a mutation in the BRCA1 or BRCA2 gene, are now being used in trials for women without these genetic mutations and showing some effect. In a recent … Continue reading
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Also tagged clinical trials, recurrence, Research, science, side effects, treatment
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Most women with BRCA mutations elect to have surgery
A new study in the journal Cancer showed that more than 80 percent of women who tested positive for a mutation in the BRCA1 or BRCA2 mutations chose to have their ovaries, breasts or both removed. These genetic mutations cause … Continue reading
Appellate Court Rules Against Patients in Gene Patent Suit
A group of advocates, led by the American Civil Liberties Union, has lost its appeal in the gene patent suit. Myriad Genetics has patented the BRCA1 and BRCA2 mutations, which are linked to breast and ovarian cancers. The suit contends … Continue reading
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Many Doctors Ignore Cancer Genetic Testing Guidelines
Less than half of doctors, according to a new study, refer women at high risk of breast or ovarian cancer to a genetic counselor but about a quarter refer average risk women to these services. See the full article here … Continue reading
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The Cancer Genome Atlas presents initial results on ovarian cancer
Earlier this week, research related to the genetics of ovarian cancer was released. The data show that there is an enormous about of genetic variation between ovarian cancers, unlike some other cancer sites. However, the study also found that a mutation … Continue reading
BRCA2 Mutation may Indicate Better Prognosis
A study of more than 3,500 women with ovarian cancer found that those with the BRCA2 mutation lived longer than those with the BRCA1 mutation or no mutation. Of women with the BRCA2 mutation, more than 60% were alive five … Continue reading
Blood Test May Spot Inherited Ovarian Cancer
Researchers are developing a blood test which they believe will be able to detect mutations in more than 20 genes that may play a role in developing ovarian cancer. The test is not available for commercial use, and studies are … Continue reading
FDA panel advises caution on personal genetic testing
An FDA advisory panel recommended that medical professionals be available to help patients undergoing personal, at-home, genetic testing. Doubts remain as to the usefulness of many of these tests, however many argue that the tests provide a service that is … Continue reading
Improved survival in non-Ashkenazi Jewish ovarian cancer patients with BRCA1 and BRCA2 gene mutations
‘Rogue gene’ discovery could brake cancers
Genetic Variation at 9p22.2 and Ovarian Cancer Risk for BRCA1 and BRCA2 Mutation Carriers (JNCI)
Background Germline mutations in the BRCA1 and BRCA2 genes are associated with increased risks of breast and ovarian cancers. Although several common variants have been associated with breast cancer susceptibility in mutation carriers, none have been associated with ovarian cancer … Continue reading
