Tag Archives: genetics

Mutation in KRAS Gene May Indicate Drug Resistance in Ovarian Cancer Patients

A genetic mutation that causes a change in the KRAS pathway appears to be linked to higher likelihood of platinum resistance in women with ovarian cancer. The KRAS pathway is … Continue reading 

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Women with BRCA2 Mutation in Ovarian Tumors have Higher Surivival Rates

A recent study shows that women with ovarian cancer who have the BRCA2 mutation live longer than those with the BRCA1 mutation. Because the BRCA1 and BRCA2 mutations works slightly … Continue reading 

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Ovarian Cancer a Mystery, Especially for Black Women

The Grio reports that African American women are not well represented in clincial trials related to ovarian cancer. The article discusses a new trial meant to explore the epidemiology of … Continue reading 

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JAAPA: When the Patient Asks – Can I be Screened for Ovarian Cancer

The JAAPA published a When the Patient Asks column on screening for ovarian cancer. WHO TO SCREEN High-risk women with a genetic mutation or strong family history should be screened. … Continue reading 

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Women with BRCA mutations getting diagnosed younger

Women with a  BRCA mutation – which increases the risk of breast and ovarian cancer – are getting diagnosed younger than their families members were. Earlier generations of women in … Continue reading 

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New Insights into BRCA1 Mechanism

A study published in Nature posits that the BRCA1 mutation prevents cancer by preventing transcription of certain kinds of DNA sequences. Women with mutations in the BRCA1 genes are at … Continue reading 

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PAPR Inhibitors May Work Against More Ovarian Cancers

PAPR inhibitors, first used in trials for women with ovarian cancer who had a mutation in the BRCA1 or BRCA2 gene, are now being used in trials for women without … Continue reading 

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Most women with BRCA mutations elect to have surgery

A new study in the journal Cancer showed that more than 80 percent of women who tested positive for a mutation in the BRCA1 or BRCA2 mutations chose to have … Continue reading 

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Appellate Court Rules Against Patients in Gene Patent Suit

A group of advocates, led by the American Civil Liberties Union, has lost its appeal in the gene patent suit. Myriad Genetics has patented the BRCA1 and BRCA2 mutations, which … Continue reading 

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Many Doctors Ignore Cancer Genetic Testing Guidelines

Less than half of doctors, according to a new study, refer women at high risk of breast or ovarian cancer to a genetic counselor but about a quarter refer average … Continue reading 

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The Cancer Genome Atlas presents initial results on ovarian cancer

Earlier this week, research related to the genetics of ovarian cancer was released. The data show that there is an enormous about of  genetic variation between ovarian cancers, unlike some other … Continue reading 

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BRCA2 Mutation may Indicate Better Prognosis

A study of more than 3,500 women with ovarian cancer found that those with the BRCA2 mutation lived longer than those with the BRCA1 mutation or no mutation. Of women … Continue reading 

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