Tag Archives: genetics
Studies Show Many Providers Think There is a Screening Test for Ovarian Cancer
Two studies released this week indicate that health care providers believe that the CA-125 and/or the transvaginal ultrasound are appropriate screening tests for ovarian cancer. There is no medical organization that has endorsed the current tools as appropriate for screening. … Continue reading
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Ovarian Cancer Patients with BRCA Mutations May Fare Better than Non-Carriers
A large meta-analysis of studies on ovarian cancer survival shows that women with the BRCA mutations survive longer after diagnosed with ovarian cancer. The research team’s analysis showed that the 5-year overall survival rate for ovarian cancer was 36 percent … Continue reading
Study Argues for Increased Use of PARP Inhibitors
A study from the Oregon Health & Science University suggests that women who have a recurrence of ovarian cancer would benefit from PARP inhibitors, now being tested in women with hereditary ovarian cancer. The study enrolled women with non-hereditary ovarian cancer, … Continue reading
DICER Mutation Found in Numerous Rare Cancers, Including Ovarian
A recent article explores the link between a number of reproductive cancers, including ovarian, uterine and testicular cancers. These cancers all have mutations in the DICER gene, warping its function. The study can be found here An article about the … Continue reading
Mutation in KRAS Gene May Indicate Drug Resistance in Ovarian Cancer Patients
A genetic mutation that causes a change in the KRAS pathway appears to be linked to higher likelihood of platinum resistance in women with ovarian cancer. The KRAS pathway is active in other types of tumors, including colorectal. Read the … Continue reading
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Women with BRCA2 Mutation in Ovarian Tumors have Higher Surivival Rates
A recent study shows that women with ovarian cancer who have the BRCA2 mutation live longer than those with the BRCA1 mutation. Because the BRCA1 and BRCA2 mutations works slightly differently, they have a different effect on survival. The BRCA2 … Continue reading
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Ovarian Cancer a Mystery, Especially for Black Women
The Grio reports that African American women are not well represented in clincial trials related to ovarian cancer. The article discusses a new trial meant to explore the epidemiology of ovarian cancer in African American women. Read the full article … Continue reading
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JAAPA: When the Patient Asks – Can I be Screened for Ovarian Cancer
The JAAPA published a When the Patient Asks column on screening for ovarian cancer. WHO TO SCREEN High-risk women with a genetic mutation or strong family history should be screened. Routine transvaginal and pelvic ultrasonography with a CA-125 test may … Continue reading
Women with BRCA mutations getting diagnosed younger
Women with a BRCA mutation – which increases the risk of breast and ovarian cancer – are getting diagnosed younger than their families members were. Earlier generations of women in the families studied were diagnosed at a median age of … Continue reading
New Insights into BRCA1 Mechanism
A study published in Nature posits that the BRCA1 mutation prevents cancer by preventing transcription of certain kinds of DNA sequences. Women with mutations in the BRCA1 genes are at higher risk of developing breast and ovarian cancer. See the … Continue reading
PAPR Inhibitors May Work Against More Ovarian Cancers
PAPR inhibitors, first used in trials for women with ovarian cancer who had a mutation in the BRCA1 or BRCA2 gene, are now being used in trials for women without these genetic mutations and showing some effect. In a recent … Continue reading
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Most women with BRCA mutations elect to have surgery
A new study in the journal Cancer showed that more than 80 percent of women who tested positive for a mutation in the BRCA1 or BRCA2 mutations chose to have their ovaries, breasts or both removed. These genetic mutations cause … Continue reading
