Author Archives: Cara

Study Argues for Increased Use of PARP Inhibitors

A study from the Oregon Health & Science University suggests that women who have a recurrence of ovarian cancer would benefit from PARP inhibitors, now being tested in women with hereditary ovarian cancer. The study enrolled women with non-hereditary ovarian cancer, … Continue reading 

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Chemotherapy Causes Changes in the Brain

According to MRI results, chemotherapy causes small changes to fibers that connect neurons in the brain. These are associated with a decline in cognitive function. Read an article about the study here

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Race, Insurance Status, Influence Treatment of Ovarian Cancer

A study of more than 47,000 women with ovarian cancer found that uninsured and Medicaid patients were less likely to receive the standard of care. Additionally, women who were African American, Hispanic or had more comorbidities or who were treated … Continue reading 

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Avastin Shown to Slow Tumor Growth; Not Prolong Life

Two studies of the use of Avastin in ovarian cancer showed that the drug slowed tumor growth but did not improve overall survival. “While we are looking for that silver bullet, this is a gift that shouldn’t be overlooked,” said … Continue reading 

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DICER Mutation Found in Numerous Rare Cancers, Including Ovarian

A recent article explores the link between a number of reproductive cancers, including ovarian, uterine and testicular cancers. These cancers all have mutations in the DICER gene, warping its function. The study can be found here An article about the … Continue reading 

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PARP Inhibitor Olarparib Fails to Meet Trial Endpoints

AstraZeneca announced that it would not continue trials of olarparib in ovarian cancer due to the results of the Phase II trial. The company’s press release is available here

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EU Approves Use of Avastin for Ovarian Cancer

The European Commission has approved the use of Avastin in women newly diagnosed with ovarian cancer. Read more on this topic here

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Bilateral Oophorectomy Associated With Higher Prevalence of Low Bone Mineral Density and Arthritis in Younger Women

A study presented at a breast cancer conference showed a link between lower bone density and removal of the ovaries. Women who had both ovaries removed before 45 years of age and who never used HRT had a lower BMD … Continue reading 

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Mutation in KRAS Gene May Indicate Drug Resistance in Ovarian Cancer Patients

A genetic mutation that causes a change in the KRAS pathway appears to be linked to higher likelihood of platinum resistance in women with ovarian cancer. The KRAS pathway is active in other types of tumors, including colorectal. Read the … Continue reading 

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Screening Study for Ovarian Cancer

A new study of 545 women with a family history of ovarian cancer were  provided annual screening with the CA-125 blood test and transvaginal ultrasound. This interval of testing with these tools did not find any early stage ovarian cancers. Read … Continue reading 

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Women’s Sexuality Altered by Diagnosis of Ovarian Cancer

A small focus group of women with ovarian cancer indicated that “Regardless of age, women reported that ovarian cancer treatment had a detrimental impact on their sexuality and that the changes made them feel ‘no longer whole.’” The article called … Continue reading 

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HE4 May be Helpful in Screening

A study based on blood samples from more than 100 ovarian cancer patients and 700 women without ovarian cancer suggested that the HE4 might be useful to use for women whose CA-125 levels are rising. Read the study abstract here

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