New Genetic Markers for Ovarian Cancer Discovered
A collaboration of more than 130 institutions analyzing data from more than 200,000 people found two new genetic markers increasing a woman’s risk of developing ovarian cancer.
New risk-modifying loci were identified for breast (n = 1) and ovarian (n = 2) cancers in BRCA1 mutation carriers and for breast cancer (n = 1) in BRCA2 mutation carriers.
An epigenetic analysis characterizing HNF1B variation in relation to ovarian cancer risk showed that different variants influence susceptibility to the serous and clear-cell subtypes.
Investigating the association between variants in putative microRNA-binding sites and ovarian cancer risk pointed to a new susceptibility locus at 17q21.13, which was also identified as one of the two new risk-modifying loci for ovarian cancer in BRCA1 mutation carriers
The results of the analysis are summarized in Table 1 of this paper.
An article about the results is available here